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Quantity: 100 ul                                                                                           Application: WB

Predicted I Observed M.W.: 34 I 52 kDa                                                      Uniprot ID: P46108

Background:

CRK is a member of an adapter protein family that binds to several tyrosin-phosphorylated proteins.  CRK has several SH2 and SH3 domains and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosin kinase through SH2-phosphotyrosin interaction.  The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.  The matured CRK are located in cytoplasm and cell membrane.

Other Names:

Adapter molecule crk, Proto-oncogene c-Crk, p38

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human CRK. Antibodies were purified by affinity purification using immunogen.

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: