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Quantity: 100 ul                                                                                 Application: WB

Predicted M.W.: 593 kDa                                                                   Uniprot ID: O14686

Background:

MLL2 is a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. MLL2 plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. MLLS acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2 is also required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation.

Other Names:

Histone-lysine N-methyltransferase 2D, MLL2, ALL1-related protein, ALR, KMT2D, Lysine N-methyltransferase 2D, Myeloid/lymphoid or mixed-lineage leukemia protein 2, MLL4

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human MLL2.  Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: