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Quantity: 100 ul                                                                                         Application: WB

Predicted I Observed M.W.: 215 I 260 kDa                                             Uniprot ID: Q8CFT2

Background:

Histone-lysine N-methyltransferase SETD1B is a histone methyltransferase that specifically methylates 'Lys-4' of histone H3 as part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression.

Other Names:

Histone-lysine N-methyltransferase SETD1B, SET domain-containing protein 1B, Kiaa1076, Set1b

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of mouse SETD1B. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

 WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: